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In a modern study, we described the identification and also the characterization of a completely new atypical opioid receptor with one of a kind adverse regulatory properties toward opioid peptides.1 Our results showed that ACKR3/CXCR7, hitherto often known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is also a wide-spectrum